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Integrative Neuroscience and Personalized Medicine$
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Evian Gordon, MD, PhD and Stephen Koslow, PhD

Print publication date: 2010

Print ISBN-13: 9780195393804

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780195393804.001.0001

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Theranostics and Translation toward Personalized Medicine for Multiple Sclerosis

Theranostics and Translation toward Personalized Medicine for Multiple Sclerosis

(p.205) Theranostics and Translation toward Personalized Medicine for Multiple Sclerosis
Integrative Neuroscience and Personalized Medicine

Ariel Miller

Tamar Paperna

Opher Caspi

Izabella Lejbkowicz

Elsebeth Staun-Ram

Nili Avidan

Oxford University Press

Recently, medicine began moving to more informed healthcare management and medical treatment guided by diagnostics, termed, theranostics. In the last decade, the search for markers for disease subtypes and more personalized treatment responses has been accelerated by academic researchers and pharmaceutical companies. Currently used high-throughput genome-wide methodology is resulting in a shift to a hypothesis-free approach to identify appropriate genes. This, in turn, has resulted in the identification of a multitude of biomarker candidates that explain a small fraction of patients’ variations in drug response therapy or disease clinical course. These research initiatives need to be followed by functional studies to determine the molecular mode of action and clinical utility of these markers. Here, the status of identification of biomarkers for diagnosis, disease course, treatment response, and related factors involved in development and response to treatment for multiple sclerosis are reviewed.

Keywords:   Multiple sclerosis, biomarkers, pharmacogenetics, theranostics, interferon beta, GWAS, microarray

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