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Integrative Neuroscience and Personalized Medicine$
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Evian Gordon, MD, PhD and Stephen Koslow, PhD

Print publication date: 2010

Print ISBN-13: 9780195393804

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780195393804.001.0001

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Autonomic Nervous System Markers for Psychophysiological, Anxiety, and Physical Disorders

Autonomic Nervous System Markers for Psychophysiological, Anxiety, and Physical Disorders

Chapter:
(p.164) 9 Autonomic Nervous System Markers for Psychophysiological, Anxiety, and Physical Disorders
Source:
Integrative Neuroscience and Personalized Medicine
Author(s):

Richard Gevirtz

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195393804.003.0009

This chapter explores the use of autonomic nervous system (ANS) measures as potential biomarkers for medically unexplained disorders. It is proposed that these disorders are better classified and treated as related symptom clusters with logical physiological and psychophysiological involving the sympathetic and parasympathetic branches of the ANS. Heart rate variability is described and several examples are given of how specific autonomic biomarkers are related to mental and physical function. Some examples from the worlds of chronic pain and gastroenterology are presented as exemplars using of a simple marker (HRV) that reflects imbalance between the body’s primary excitatory and inhibitory systems, that can readily be linked to gene-brain personalized medicine markers underlying excitation-inhibitory imbalances in brain-based disorders.

Keywords:   Autonomic nervous system, vagal biomarkers, heart rate variability, mediational model

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