Personalized Medicine and Integrative Neuroscience: Toward Consensus Markers for Disorders of Brain Health
In the emerging new paradigm of “Personalized Medicine,” the goal is to shift the treatment for brain-related illness from trial and error into a bull’s-eye. To date, much of the research in Personalized Medicine has focused on genetic “markers” employed as predictors of individual treatment response. The complexity of the brain requires a shift in focus from genetic marker(s) to an integrated approach, in which a wider scope of molecular plus brain-related functional, structural and cognitive information is used in a complementary manner. This chapter provides a brief summary of the current evidence for markers that predict brain-related treatment response in depression, schizophrenia and ADHD. The chapter focuses on the current status of Personalized Medicine, including the principles of an integrative approach to personalized medicine for the brain, and building a new taxonomy for incorporating the most clinically effective markers, is also outlined.
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