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Integrative Neuroscience and Personalized Medicine$
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Evian Gordon, MD, PhD and Stephen Koslow, PhD

Print publication date: 2010

Print ISBN-13: 9780195393804

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780195393804.001.0001

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Personalized Medicine and Integrative Neuroscience: Toward Consensus Markers for Disorders of Brain Health

Personalized Medicine and Integrative Neuroscience: Toward Consensus Markers for Disorders of Brain Health

Chapter:
(p.25) 3 Personalized Medicine and Integrative Neuroscience: Toward Consensus Markers for Disorders of Brain Health
Source:
Integrative Neuroscience and Personalized Medicine
Author(s):

Leanne M. Williams

Evian Gordon

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195393804.003.0003

In the emerging new paradigm of “Personalized Medicine,” the goal is to shift the treatment for brain-related illness from trial and error into a bull’s-eye. To date, much of the research in Personalized Medicine has focused on genetic “markers” employed as predictors of individual treatment response. The complexity of the brain requires a shift in focus from genetic marker(s) to an integrated approach, in which a wider scope of molecular plus brain-related functional, structural and cognitive information is used in a complementary manner. This chapter provides a brief summary of the current evidence for markers that predict brain-related treatment response in depression, schizophrenia and ADHD. The chapter focuses on the current status of Personalized Medicine, including the principles of an integrative approach to personalized medicine for the brain, and building a new taxonomy for incorporating the most clinically effective markers, is also outlined.

Keywords:   Personalized Medicine, Integrative Neuroscience, genomics, brain imaging, cognition, emotion, clinical decision support, diagnosis, treatment, depression, schizophrenia, ADHD

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