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Integrative Neuroscience and Personalized Medicine$
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Evian Gordon, MD, PhD and Stephen Koslow, PhD

Print publication date: 2010

Print ISBN-13: 9780195393804

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780195393804.001.0001

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An Applied Context for Personalized Medicine in Psychiatry

An Applied Context for Personalized Medicine in Psychiatry

(p.17) 2 An Applied Context for Personalized Medicine in Psychiatry
Integrative Neuroscience and Personalized Medicine

Alan F. Schatzberg

Oxford University Press

This chapter reviews a number of early hypotheses about the role of neurotransmitters in depression. These hypotheses had some potential, but never had the impact one might have hoped for in the effort to shed light on the problems faced in personalized medicine in psychiatry. Psychiatry is hampered by its inherent inability to physically access the brain. Biopsies are not routinely performed to study illnesses such as depression, and, until recently, imaging the central nervous system was at best crude and at times painful for the patient. Recent advances in understanding genetics and depression, as well as results from brain imaging studies, provide opportunities for developing more targeted tests that hopefully are less affected by extraneous events. Still, the earlier experiences do provide some context, and lessons that can be used to develop more effectively personalized medicine for psychiatry.

Keywords:   depression, neurotransmitters, personalized medicine, psychiatry, biopsy, genetics

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