Functional Markers of Cognition in Parkinson’s Disease
18F-FDG and H2 15O Positron Emission Tomography Studies
Cognitive and behavioral problems are common in patients with Parkinson’s disease (PD), with the prevalence of dementia in patients with PD conservatively estimated to range between 24% and 31%. Functional brain imaging with PET and fMRI has contributed greatly to the understanding of cognitive disturbances in PD and are reviewed in this chapter. The chapter discusses the characterization of specific rest-state spatial covariance patterns (metabolic networks) associated with cognitive dysfunction in PD patients. Also addressed is the utility of these networks for objectively evaluating the progression of PD-related cognitive manifestations and their response to treatment. In depth discussion is also provided of the disease-related changes in brain activation responses that take place during cognitive processing as highlighted by imaging studies of sequence learning tasks.
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