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Imaging in Parkinson’s Disease$
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David Eidelberg

Print publication date: 2011

Print ISBN-13: 9780195393484

Published to Oxford Scholarship Online: September 2011

DOI: 10.1093/acprof:oso/9780195393484.001.0001

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Structural Abnormalities in Parkinson’s Disease

Structural Abnormalities in Parkinson’s Disease

MRI and Related Methods

Chapter:
(p.32) 4 Structural Abnormalities in Parkinson’s Disease
Source:
Imaging in Parkinson’s Disease
Author(s):

Kathrin Reetz

Ferdinand Binkofski

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195393484.003.0027

The traditional role of MRI in parkinsonism is to exclude secondary causes of symptoms. Recent advances in MR methodology, including voxel-based morphometry, diffusion imaging, and inversion recovery sequences, have yielded new tools for the detection of nigral and extra-nigral pathology in PD. These advanced anatomical and functional MR techniques have substantially improved the accuracy of differential diagnosis and contributed to the understanding of the pathophysiology of the parkinsonian disorders. In this chapter, the authors provide a comprehensive review of MR applications for the study of PD. They also include interesting material on the use of these approaches in the assessment of cognitive and affective disease manifestations in PD patients and the evaluation of individuals with disease-related genetic mutations.

Keywords:   Parkinson’s disease, voxel-based morphometry, diffusion-tensor MR, cognitive impairment, Parkinson’s disease dementia, PD-related genetic mutations

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