This chapter presents an autobiography of Hans Thoenen. Thoenen elucidated the mechanism of action of 6-hydroxydopamine that led to the serendipitous detection of trans-synaptic enzyme induction. Subsequently his laboratory made crucial contributions to the field of neurotrophic factors, including the cloning of brain derived neurotrophic and ciliary neurotrophic factor and the analysis of their physiological functions. His early years, career, and achievements are discussed.
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