Jump to ContentJump to Main Navigation
Dopamine Handbook
Users without a subscription are not able to see the full content.

Dopamine Handbook

Leslie Iversen, Susan Iversen, Stephen Dunnett, and Anders Bjorklund

Abstract

The discovery of dopamine in 1957-8 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurological and psychiatric disorders. Dopamine has a fundamental role in almost all aspects of behavior — from motor control to mood regulation, cognition and addiction and reward — and dopamine research has been unique within the neurosciences in the way it has bridged basic science and clinical practice. Over the decades, research into the role of dopamine in health and disease has been at the forefront of m ... More

Keywords: dopamine, neurological disorders, psychiatric disorders, motor control, mood regulation, cognition, addiction

Bibliographic Information

Print publication date: 2009 Print ISBN-13: 9780195373035
Published to Oxford Scholarship Online: February 2010 DOI:10.1093/acprof:oso/9780195373035.001.0001

Authors

Affiliations are at time of print publication.

Leslie Iversen, Editor
Oxford University, UK

Susan Iversen, Editor
Oxford University, UK

Stephen Dunnett, Editor
Cardiff University, UK

More

Reviews

More by Leslie L. Iversen

Contents

View:

Front Matter

Title Pages

Preface

Contributors

1 Overview: A personal view of the dopamine neuron in historical perspective

Introduction

2 Neuroanatomy

2.1 Functional Neuroanatomy of Dopamine in the Striatum

2.2 Functional Implications of Dopamine D2 Receptor Localization in Relation to Glutamate Neurons

2.3 Convergence of Limbic, Cognitive, and Motor Cortico-Striatal Circuits with Dopamine Pathways in Primate Brain

2.4 The Relationship between Dopaminergic Axons and Glutamatergic Synapses in the Striatum: Structural Considerations

3 Molecular pharmacology

3.1 Molecular Pharmacology of the Dopamine Receptors

3.2 Role of Dopamine Transporters in Neuronal Homeostasis

3.3 Intracellular Dopamine Signaling

3.4 Ion Channels and Regulation of Dopamine Neuron Activity

4 Genes in development

4.1 Genetic Control of Meso-diencephalic Dopaminergic Neuron Development in Rodents

4.2 Factors Shaping Later Stages of Dopamine Neuron Development

4.3 Postnatal Maturation of Dopamine Actions in the Prefrontal Cortex

4.4 Genetic Dissection of Dopamine-Mediated Prefrontal-Striatal Mechanisms and Its Relationship to Schizophrenia

5 Dopamine in prefrontal cortex and cognition

5.1 From Behavior to Cognition: Functions of Mesostriatal, Mesolimbic, and Mesocortical Dopamine Systems

5.2 Contributions of Mesocorticolimbic Dopamine to Cognition and Executive Function

5.3 Dopamine’s Influence on Prefrontal Cortical Cognition: Actions and Circuits in Behaving Primates

5.4 Dopaminergic Modulation of Flexible Cognitive Control in Humans

5.5 Neurocomputational Analysis of Dopamine Function

6 Striatum and midbrain—motor and motivational functions

6.1 Dopamine and Motor Function in Rat and Mouse Models of Parkinson’s Disease

6.2 Involvement of Nucleus Accumbens Dopamine in Behavioral Activation and Effort-Related Functions

6.3 Functional Heterogeneity in Striatal Subregions and Neurotransmitter Systems: Implications for Understanding the Neural Substrates Underlying Appetitive Motivation and Learning

6.4 Behavioral Functions of Dopamine Neurons

7 Plasticity of forebrain dopamine systems

7.1 Dynamic Templates for Neuroplasticity in the Striatum

7.2 Dopamine and Synaptic Plasticity in Mesolimbic Circuits

7.3 Dopaminergic Modulation of Striatal Glutamatergic Signaling in Health and Parkinson’s Disease

8 Dopamine mechanisms in addiction

8.1 The Role of Dopamine in the Motivational Vulnerability to Addiction

8.2 Dopaminergic Mechanisms in Drug-Seeking Habits and the Vulnerability to Drug Addiction

8.3 Imaging Dopamine’s Role in Drug Abuse and Addiction

9 Parkinson’s disease

9.1 Exploring the Myths about Parkinson’s Disease

9.2 Pathophysiology of L-DOPA-Induced Dyskinesia in Parkinson's Disease

9.3 Progression of Parkinson’s Disease Revealed by Imaging Studies

9.4 Transplantation of Dopamine Neurons: Extent and Mechanisms of Functional Recovery in Rodent Models of Parkinson's Disease

9.5 Clinical Experiences with Dopamine Neuron Replacement in Parkinson’s Disease: What Is the Future?

9.6 Novel Gene-Based Therapeutics Targeting the Dopaminergic System in Parkinson’s Disease

9.7 Neuroprotective Strategies in Parkinson’s Disease

10 Schizophrenia and other psychiatric illnesses

10.1 Dopamine Dysfunction in Schizophrenia

10.2 Neuropharmacological Profiles of Antipsychotic Drugs

10.3 How Antipsychotics Work: Linking Receptors to Response

10.4 Dopamine Dysfunction in Schizophrenia: From Genetic Susceptibility to Cognitive Impairment

10.5 The Role of Dopamine in the Pathophysiology and Treatment of Major Depressive Disorder

10.6 Dopamine Modulation of Forebrain Pathways and the Pathophysiology of Psychiatric Disorders

End Matter

Index