Jump to ContentJump to Main Navigation
Dopamine Handbook$
Users without a subscription are not able to see the full content.

Leslie Iversen, Susan Iversen, Stephen Dunnett, and Anders Bjorklund

Print publication date: 2009

Print ISBN-13: 9780195373035

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780195373035.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a monograph in OSO for personal use (for details see www.oxfordscholarship.com/page/privacy-policy).date: 21 April 2019

Role of Dopamine Transporters in Neuronal Homeostasis

Role of Dopamine Transporters in Neuronal Homeostasis

(p.88) 3.2 Role of Dopamine Transporters in Neuronal Homeostasis
Dopamine Handbook

Marc G. Caron

Raul R. Gainetdinov

Oxford University Press

Dopamine (DA) neurotransmission is controlled by several critical processes. A complex homeostatic balance between the amount of DA synthesized, packaged into vesicles, released, reuptaken via plasma membrane transporter and metabolized, determines the overall status of dopaminergic signaling. The plasma membrane dopamine transporter (DAT) provides effective control of both the extracellular and intracellular concentrations of DA by recapturing released neurotransmitters in the presynaptic terminals. The vesicular monoamine transporter 2 (VMAT2) directly controls vesicular storage and release capacity by pumping monoamines from the cytoplasm of neurons into synaptic vesicles. These transporters are primary targets of many psychotropic drugs that potently affect synaptic DA and related physiological processes. This chapter summarizes recent advances in the understanding of the molecular and cellular mechanisms involved in the DAT and VMAT2 functions. It discusses the role of these transporters in the action of psychostimulant drugs and neurotoxins, as revealed in studies using mutant mice.

Keywords:   dopamine neurotransmission, vesicular monoamine transporter 2, dopamine transporter, DA homeostasis

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .