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Dopamine Handbook$
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Leslie Iversen, Susan Iversen, Stephen Dunnett, and Anders Bjorklund

Print publication date: 2009

Print ISBN-13: 9780195373035

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780195373035.001.0001

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The Role of Dopamine in the Motivational Vulnerability to Addiction

The Role of Dopamine in the Motivational Vulnerability to Addiction

(p.371) 8.1 The Role of Dopamine in the Motivational Vulnerability to Addiction
Dopamine Handbook

George F. Koob

Michel Le Moal

Oxford University Press

This chapter discusses the role of dopamine in addiction. Research over the past 50 years has revealed that the mesocorticolimbic dopamine system has an essential role in the acute reinforcing effects of psychostimulant drugs and a contributory role in the acute reinforcing effects of nonstimulant drugs of abuse. Mesocorticolimbic dopamine systems contribute to motivational withdrawal and relapse with all drugs of abuse, and dopamine, by interacting with key elements of brain hormonal stress systems, also has a prominent role in individual differences for the vulnerability to initiate aspects of stimulant addiction that may extend to other drugs of abuse.

Keywords:   dopamine, addiction, drug abuse, mesocorticolimbic dopamine system

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