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Dopamine Handbook
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Dopamine Handbook

Leslie Iversen, Susan Iversen, Stephen Dunnett, and Anders Bjorklund

Abstract

The discovery of dopamine in 1957-8 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurological and psychiatric disorders. Dopamine has a fundamental role in almost all aspects of behavior — from motor control to mood regulation, cognition and addiction and reward — and dopamine research has been unique within the neurosciences in the way it has bridged basic science and clinical practice. Over the decades, research into the role of dopamine in health and disease has been at the forefront of m ... More

Keywords: dopamine, neurological disorders, psychiatric disorders, motor control, mood regulation, cognition, addiction

Bibliographic Information

Print publication date: 2009 Print ISBN-13: 9780195373035
Published to Oxford Scholarship Online: February 2010 DOI:10.1093/acprof:oso/9780195373035.001.0001

Authors

Affiliations are at time of print publication.

Leslie Iversen, editor
Oxford University, UK
Author Webpage

Susan Iversen, editor
Oxford University, UK
Author Webpage

Stephen Dunnett, editor
Cardiff University, UK

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Contents

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1 Overview: A personal view of the dopamine neuron in historical perspective

Introduction

Floyd E. Bloom

2 Neuroanatomy

3 Molecular pharmacology

3.1 Molecular Pharmacology of the Dopamine Receptors

Michele L. Rankin, Lisa A. Hazelwood, R. Benjamin Free, Yoon Namkung, Elizabeth B. Rex, Rebecca A. Roof, and David R. Sibley

3.2 Role of Dopamine Transporters in Neuronal Homeostasis

Marc G. Caron, and Raul R. Gainetdinov

4 Genes in development

5 Dopamine in prefrontal cortex and cognition

5.3 Dopamine’s Influence on Prefrontal Cortical Cognition: Actions and Circuits in Behaving Primates

Amy F.T. Arnsten, Susheel Vijayraghavan, Min Wang, Nao J. Gamo, and Constantinos D. Paspalas

6 Striatum and midbrain—motor and motivational functions

7 Plasticity of forebrain dopamine systems

7.2 Dopamine and Synaptic Plasticity in Mesolimbic Circuits

F. Woodward Hopf, Antonello Bonci, and Robert C. Malenka

7.3 Dopaminergic Modulation of Striatal Glutamatergic Signaling in Health and Parkinson’s Disease

D. James Surmeier, Michelle Day, Tracy S. Gertler, C. Savio Chan, and Weixing Shen

8 Dopamine mechanisms in addiction

8.2 Dopaminergic Mechanisms in Drug-Seeking Habits and the Vulnerability to Drug Addiction

Barry J. Everitt, David Belin, Jeffrey W. Dalley, and Trevor W. Robbins

8.3 Imaging Dopamine’s Role in Drug Abuse and Addiction

Nora D. Volkow, Joanna S. Fowler, Gene-Jack Wang, Frank Telang, and Ruben Baler

9 Parkinson’s disease

9.1 Exploring the Myths about Parkinson’s Disease

Yves Agid, and Andreas Hartmann

9.6 Novel Gene-Based Therapeutics Targeting the Dopaminergic System in Parkinson’s Disease

Deniz Kirik, Tomas Björklund, Shilpa Ramaswamy, and Jeffrey H. Kordower

10 Schizophrenia and other psychiatric illnesses

10.1 Dopamine Dysfunction in Schizophrenia

Anissa Abi-Dargham, Mark Slifstein, Larry Kegeles, and Marc Laruelle

End Matter