Genetic Control of Cajal–Retzius Cell Development
This chapter discusses recent evidence on the genetic factors controlling Cajal–Retzius (C-R) cell production, differentiation, and migration during corticogenesis. Topics covered include genetic determinants of C-R cell differentiation, routes of C-R cell migration, and subtypes of C-R cells generated by distinct progenitor domains. It is shown that C-R cells are a heterogeneous population formed by distinct subtypes generated in different focal sites at pallial and subpallial locations that migrate toward the dorsal pallium following stereotyped routes. C-R cell subtypes differ not only in their place of origin and migratory routes but also in their gene expression profile.
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