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From Development to Degeneration and Regeneration of the Nervous System$
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Charles E. Ribak, Carlos Aramburo de la Hoz, Edward G. Jones, Jorge A. Larriva Sahd, and Larry W. Swanson

Print publication date: 2008

Print ISBN-13: 9780195369007

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195369007.001.0001

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Alzheimer’s Disease–Related Mechanisms of Neuronal Dysfunction and Degeneration: Studies in Human Cortical Neurons

Alzheimer’s Disease–Related Mechanisms of Neuronal Dysfunction and Degeneration: Studies in Human Cortical Neurons

Chapter:
(p.183) Chapter Ten Alzheimer’s Disease–Related Mechanisms of Neuronal Dysfunction and Degeneration: Studies in Human Cortical Neurons
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From Development to Degeneration and Regeneration of the Nervous System
Author(s):

Jorge Busciglio

Atul Deshpande

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195369007.003.0010

This chapter reviews recent work illustrating the utilization of human cortical neurons for the study of molecular mechanisms of β-amyloid (Aβ) and tau-related neuronal degeneration relevant to Alzheimer's disease (AD). It shows that the emerging view of multiple Aβ species capable of deleterious effects at multiple levels co-existing in AD will require a refined therapeutic strategy to address Aβ-mediated neurotoxicity. A specific and complex pattern of tau isoform expression has been observed in human cortical neurons (HCN), which may play a critical role in the development of human tauopathies.

Keywords:   β-amyloid, neurodegeneration, neurons, tau isoforms, human tauopathies

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