Epileptiform Discharges In Vitro
VFO precedes electrographic seizures in vitro, as well as in vivo. The in vitro VFO is gap junction dependent, and is observed most readily in conditions when synaptic transmission is suppressed. One hypothesis as to seizure initiation is that synaptic excitation recovers prior to synaptic inhibition, so that classical synaptically mediated seizure discharges can arise. Epileptiform discharges in vivo can also be preceded by gamma oscillations, and there is an in vitro model in which gamma activity and bursting activity alternates. The alternating activity appears to arise because of use-dependent alterations in synaptic excitation and inhibition.
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