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Imaging the Aging Brain
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Imaging the Aging Brain

William Jagust and Mark D'Esposito

Abstract

The study of brain aging has been revolutionized through advances in molecular neuroscience, cognitive neuroscience, and brain imaging. The application of new concepts and techniques has permitted investigators to explore the changes in structure, function, and biochemistry in living humans in order to unravel mechanisms that underlie both age-related cognitive decline and preservation of cognition into old age. This book reviews both the basic science and clinical applications of brain imaging in the study of brain aging. Topics reviewed include technical issues associated with imaging studie ... More

Keywords: PET, MRI, fMRI, dopamine, vascular disease, diagnosis, prediction, aging, dementia, function, structure, biochemistry

Bibliographic Information

Print publication date: 2009 Print ISBN-13: 9780195328875
Published to Oxford Scholarship Online: February 2010 DOI:10.1093/acprof:oso/9780195328875.001.0001

Authors

Affiliations are at time of print publication.

William Jagust, editor
University of California, Berkeley

Mark D'Esposito, editor
University of California, Berkeley

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Contents

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1 Introduction: Still More Questions than Answers

William Jagust, and Mark D’Esposito

2 Methodological and Conceptual Issues in the Study of the Aging Brain

Mark D’Esposito, William Jagust, and Adam Gazzaley

3 Neuropathology of Aging

Dara L. Dickstein, John H. Morrison, and Patrick R. Hof

Part I Basic Science

5 Dopaminergic Modulation of Cognition in Human Aging

Shu-Chen Li, Ulman Lindenberger, Lars Nyberg, Hauke R. Heekeren, and Lars Bäckman

Part II Clinical Applications

11 The Early Detection of Alzheimer's Disease with Positron Emission Tomography

Rachel Mistur, Lisa Mosconi, Remigiusz Switalski, Susan De Santi, Yi Li, Lidia Glodzik, Miroslaw Brys, Wai Tsui, Henry Rusinek, and Mony J. de Leon

14 Amyloid Imaging and (What is “Normal”?) Aging

William E. Klunk, and Chester A. Mathis

15 Differential Diagnosis of Dementia Using Functional Neuroimaging

Eric Salmon, Fabienne Collette, and Gaëtan Garraux

16 MRI and the Differential Diagnosis of Dementia

António J. Bastos-Leite, and Philip Scheltens

17 White Matter Hyperintensities in Aging and Dementia

Adriane Mayda, Mitsuhiro Yoshita, and Charles DeCarli

21 Databasing the Aging Brain

John Darrell, Van Horn, and Arthur W. Toga

End Matter