For several decades the incidence of NHL has increased more rapidly than that of almost any other cancer. Established risk factors such as immunosuppression, autoimmunity, and certain infectious agents explain at most only a small fraction of the cases. Other possible risk associations include particular food products, medications, pesticides, and hair dyes. Recent evaluations of epidemiologic patterns of NHL according to histologic subtype have documented clear differences among the different NHL subtypes, which strongly suggests they may also have different risk factor profiles.
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