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Adolescent Psychopathology and the Developing BrainIntegrating Brain and Prevention Science$
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Daniel Romer and Elaine F. Walker

Print publication date: 2007

Print ISBN-13: 9780195306255

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195306255.001.0001

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Neurohormones, Neurodevelopment, and the Prodrome of Psychosis in Adolescence

Neurohormones, Neurodevelopment, and the Prodrome of Psychosis in Adolescence

Chapter:
(p.264) Chapter 12 Neurohormones, Neurodevelopment, and the Prodrome of Psychosis in Adolescence
Source:
Adolescent Psychopathology and the Developing Brain
Author(s):

Elaine F. Walker

Amanda McMillan

Vijay Mittal

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195306255.003.0012

It has been suggested that the neural systems governing the response to stress, especially the hypothalamic-pituitary-adrenal (HPA) axis, may function to augment the expression of the core vulnerability to psychosis. This chapter reviews research findings that bear on adolescent vulnerability for psychosis and neurodevelopment of the HPA-hippocampal system, with an emphasis on implications for preventive intervention. The chapter presents preliminary data from recent research that suggests how psychopharmacologic interventions might alter HPA function, and thereby modify the transition to psychosis in at-risk adolescents.

Keywords:   hypothalamic-pituitary-adrenal axis, psychosis, stress, HPA function

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