Genetic Epidemiology for Case-Based Designs
Genetic epidemiology is one of the most rapidly growing fields of epidemiologic research. Almost every human disease has some genetic component. The main purpose of genetic epidemiology is to identify genes that cause, or contribute to risk for human disease. The central paradigm for the identification of genes that contribute to disease risk involves a set of questions and design/analytic strategies to answer those questions. This chapter presents different types of measuring genetic variables. The use of the case-control design in genetic epidemiology is presented through various methods of analysis such as regression models and genetic models. The chapter also describes the various components of the case-parent trio design as well as the case only design, including various approaches of analysis.
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