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Brain DevelopmentNormal Processes and the Effects of Alcohol and Nicotine$
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Michael W. Miller

Print publication date: 2006

Print ISBN-13: 9780195183139

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780195183139.001.0001

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Nicotinic Receptor Regulation of Developing Catecholamine Systems

Nicotinic Receptor Regulation of Developing Catecholamine Systems

Chapter:
(p.381) 23 Nicotinic Receptor Regulation of Developing Catecholamine Systems
Source:
Brain Development
Author(s):

Frances M. Leslie

Layla Azam

Kathy Gallardo

Kathryn O’Leary

Ryan Franke

Shahrdad Lotfipour

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195183139.003.0023

Nicotine binds to specific cholinergic receptors. A nicotinic acetylcholine receptor (nAChR) is a ligand-gated cation channel. Each receptor consists of five subunit proteins surrounding a channel pore that mediate many of the biological effects of acetylcholine. This chapter uses a combination of biochemical, anatomical, and behavioral approaches to evaluate the hypothesis that functional nAChRs are expressed on catecholamine neurons during critical phases of brain development.

Keywords:   nicotinic acetylcholine receptors, neurons, catecholamine neurons

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