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Brain DevelopmentNormal Processes and the Effects of Alcohol and Nicotine$
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Michael W. Miller

Print publication date: 2006

Print ISBN-13: 9780195183139

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780195183139.001.0001

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Neural Precursors as Preferential Targets for Drug Abuse: Long-Term Consequences and Latent Susceptibility to Central Nervous System Disorders

Neural Precursors as Preferential Targets for Drug Abuse: Long-Term Consequences and Latent Susceptibility to Central Nervous System Disorders

Chapter:
(p.363) 22 Neural Precursors as Preferential Targets for Drug Abuse: Long-Term Consequences and Latent Susceptibility to Central Nervous System Disorders
Source:
Brain Development
Author(s):

Kurt F. Hauser

Nazira El-Hage

Shreya Buch

Gregory N. Barnes

Henrietta S. Bada

James R. Pauly

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195183139.003.0022

Considerable evidence suggests that drugs with abuse liability disrupt development by affecting the production of new neurons and glia. The effects of drug abuse are not limited to a particular cell type, germinal zone, or stage of development, but rather uniquely affect individual neuronal and glial precursor types with various germinal zones. Germinal zones are targeted to varying degrees by most substance with abuse liability. This chapter discusses the effects of opiates and nicotine on the genesis of neural cells.

Keywords:   drug abuse, development, neurons, opiates, germinal zone

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