The Role of Estrogen Receptors in the Regulation of Aggressive Behaviors
At least two types of estrogen receptors (ERs), the classical ER-α and the more recently identified ER-β, have been localized in the central nervous system. ER-α and ER-β are very similar estrogen binding proteins that act as ligand-dependent transcription factors. Although somewhat overlapping, brain distributions of ER-α and ER-β are not identical. This chapter summarizes current knowledge of the possible differential roles played by the two types of ERs in the expression of aggressive behavior. It also discusses potential brain mechanisms of ER-mediated regulation of aggression.
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