This chapter presents a brief overview of the functioning of the immune system, followed by a description of how immune alterations can affect central nervous system (CNS) processes and behavior in the rat. It also describes how factors that have an impact on psychological processes, most notably stressors, may come to affect immune functioning. In so doing, it introduces numerous caveats concerning the conditions and limitations that determine the nature of the effects observed, making it clear that disentangling the impact of various manipulations on immune activity is complex.
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