Second Messenger Systems
This chapter focuses on recent developments in (predominantly astro-) glial second messenger pathways, particularly those involved in intracellular Ca2+ signaling. It illustrates signaling cascades in glia by reference to the regulation of expression and activity of the nitric oxide synthases (NOS). The product of NOS activity, nitric oxide (NO), then interacts with numerous other molecules, including cyclooxygenase (COX)-2. The chapter draws attention to the evidence for assemblies of signaling molecules. Compared with highly polarized endothelial cells and neurons, little attention has been paid to such compartmentation within glia.
Keywords: glial cells, second messenger pathways, intracellular signaling, nitric oxide synthase, cyclooxygenase
Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.
Please, subscribe or login to access full text content.
If you think you should have access to this title, please contact your librarian.
To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .