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Cancer Epidemiology and Prevention$
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David Schottenfeld and Joseph F. Fraumeni

Print publication date: 2006

Print ISBN-13: 9780195149616

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780195149616.001.0001

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The Leukemias

The Leukemias

Chapter:
(p.841) 44 The Leukemias
Source:
Cancer Epidemiology and Prevention
Author(s):

MARTHA S. LINET

SUSAN S. DEVESA

GARETH J. MORGAN

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195149616.003.0044

The leukemias arise from malignant transformation of hematopoietic stem or progenitor cells that originate in the bone marrow, lymph nodes, and/or other lymphoid tissue with immune function. A small pool of stem cells, which persists throughout an individual's lifetime, differentiates to early precursors, then divides into multiple subtypes, and ultimately produces large numbers of end-stage cells of myeloid and lymphoid lineage progeny. Because the effector or end-stage cells of each lineage have a finite lifespan and, therefore, cannot transmit mutations, all leukemias are the consequence of derangements of growth and differentiation of the pluripotential early precursors of myeloid or lymphoid progeny. This chapter discusses the epidemiology of the myeloid and lymphoid leukemias.

Keywords:   myeloid leukemia, lymphoid leukemia, cancer risk, cancer epidemiology, cancer prevention, lympth nodes

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