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Cancer Epidemiology and Prevention$
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David Schottenfeld and Joseph F. Fraumeni

Print publication date: 2006

Print ISBN-13: 9780195149616

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780195149616.001.0001

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Molecular and Genetic Events in Neoplastic Transformation

Molecular and Genetic Events in Neoplastic Transformation

Chapter:
(p.47) 4 Molecular and Genetic Events in Neoplastic Transformation
Source:
Cancer Epidemiology and Prevention
Author(s):

AYSE E. ERSON

ELIZABETH M. PETTY

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195149616.003.0004

This chapter illustrates some of the basic molecular and genetic mechanisms that underlie the development of cancer. The chapter is organized into four main sections. The first section examines perspectives on the roles of oncogenes, tumor suppressor genes, and genomic instability genes in the pathogenesis of malignancy. The second section presents the genetic and epigenetic alterations that disrupt normal function of cancer genes. The third section discusses the alteration of cell cycle progression and checkpoint mechanisms relative to their possible contribution to carcinogenesis. The last section summarizes the phenotypic characteristics of cancer cells, including proliferation, apoptosis, angiogenesis, and metastasis as related to specific molecular events.

Keywords:   cancer development, cancer genes, cancer cells, oncogenes, tumor suppressor genes, genomic instability, malignancy

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