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Cancer Epidemiology and Prevention$
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David Schottenfeld and Joseph F. Fraumeni

Print publication date: 2006

Print ISBN-13: 9780195149616

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780195149616.001.0001

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Immunologic Factors

Immunologic Factors

Chapter:
(p.549) 27 Immunologic Factors
Source:
Cancer Epidemiology and Prevention
Author(s):

GARETH J. MORGAN

MARTHA S. LINET

CHARLES S. RABKIN

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195149616.003.0027

This chapter discusses the immunologic factors in cancer. Topics covered include structure and function of the immune system, immune variation and cancer risk, and age-related changes in immune function. Experience with a wide range of immune deficient conditions indicates that loss of immune competence does not globally increase cancer incidence. Limited sets of malignancies are increased that are specific to the underlying immune abnormalities. A common feature is the prominent excess of non-Hodgkin lymphoma (NHL) in many of these disorders.

Keywords:   cancer risk, immune system, immune function, non-Hodgkin lymphoma

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