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Mechanisms of Synaptic Transmission$
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Joseph D. Robinson

Print publication date: 2001

Print ISBN-13: 9780195137613

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780195137613.001.0001

Identifying Neurotransmitters (1946–1976)

Chapter:
(p. 119 ) 5 Identifying Neurotransmitters (1946–1976)
Source:
Mechanisms of Synaptic Transmission
Author(s):

Joseph D. Robinson

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195137613.003.0005

This chapter describes further experiments in identifying neurotransmitters in the central nervous system. After decades of concentration on acetylcholine and adrenaline/noradrenaline, new studies shifted the focus. Glutamate turned out to be the major excitatory neurotransmitter in the brain as well as the sensory neurotransmitter of dorsal root ganglion cells. GABA turned out to be the major inhibitory neurotransmitter in the brain, with glycine a prominent inhibitory neurotransmitter in the spinal cord. Furthermore, considerations of pathologies and therapeutics fostered an interest in many of the more newly established neurotransmitters, notably dopamine, serotonin, GABA, and enkephalin.

Keywords:   neurotransmitters, central nervous system, glutamate, GABA, glycine, dopamine, serotonin, enkephalin

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