Jump to ContentJump to Main Navigation
NeuroepidemiologyFrom principles to practice$
Users without a subscription are not able to see the full content.

Lorene M. Nelson, Caroline M. Tanner, Stephen Van Den Eeden, and Valarie M. McGuire

Print publication date: 2004

Print ISBN-13: 9780195133790

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780195133790.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a monograph in OSO for personal use (for details see www.oxfordscholarship.com/page/privacy-policy).date: 26 March 2019

Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis

Chapter:
(p.162) 7 Amyotrophic Lateral Sclerosis
Source:
Neuroepidemiology
Author(s):

Lorene M. Nelson

Caroline M. Tanner

Stephen K. Van Den Eeden

Valerie M. McGuire

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195133790.003.07

This chapter focuses on amyotrophic lateral sclerosis (ALS), the most common motor neuron disease. It discusses the three major forms of ALS: sporadic ALS, the familial or hereditary form of ALS, and the western Pacific (Mariana Islands) form. Considerable progress has been made in recent years on identifying genetic loci responsible for Mendelian forms of ALS; this evidence is summarized. The potential importance of geographic clusters is discussed, with particular emphasis on the western Pacific form of ALS because it often occurs in association with a parkinsonism and/or dementia complex (PDC). The incidence of Western Pacific ALS peaked and then declined in the mid-20th century, which strongly implicated an environmental cause. The chapter also presents detailed information regarding putative risk factors for sporadic ALS, which includes environmental toxicants, skeletal trauma, cigarette smoking, diet, and vigorous physical activity.

Keywords:   motor neuron disease, ALS, western Pacific ALS, sporadic ALS, risk factors, environmental toxicants, geographic clusters, smoking, diet, physical activity

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .