Depression in Rodents and Humans
Commentary on Jay Weiss
This chapter examines the nonhuman model of depression discussed in the previous chapter from the perspective of humans. The first section discusses important considerations in applying nonhuman animal models to study the psychology and biology of human depression. The clinical procedures and findings of Jay Weiss' studies on stress-induced depression (SID) in rodents are reviewed and presented, followed by a discussion on the reasons why psychomotor retardation is considered the behavioral index of choice for assessing SID. Also presented are updates on the SID model which consider the effects and influences of the neuropeptide galanin on the original methodology. A section is also devoted to the role of the amygdala in SID through its participation in the generation and regulation of affective processes. Studies on the neuroanatomy of SID are also summarized along with comments on the differences in time-course between human and rodent depression.
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