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Laboratory Reference for Clinical Neurophysiology$
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Jay A. Liveson and Dong M. Ma

Print publication date: 1999

Print ISBN-13: 9780195129243

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780195129243.001.0001

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Cognitive Event-Related Studies

Cognitive Event-Related Studies

(p.353) Chapter 16 Cognitive Event-Related Studies
Laboratory Reference for Clinical Neurophysiology

Jay A. Liveson

Dong M. Ma

Oxford University Press

P300 potentials are slow waves that depend on stimuli containing information that the subject must process. The types of stimuli are independent of the sensory modality of the stimuli, and have included auditory, visual, and tactile, among others. The function of these potentials is controversial, but it best correlates with evaluation time when unpredictable events have to be discriminated. At present, these studies can be helpful in distinguishing organic dementia (such as in Alzheimer's disease) from the pseudodementia associated with depression. P300 potentials can be used to evaluate drugs. In addition, abnormalities have been found in schizophrenics, alcoholics and their families, and patients with chronic renal failure. A pre-recorded sequence of intermixed tones is presented in two manners. At first, the subject is instructed to ignore the tone (“ignore” condition). Secondly, the subject is instructed to distinguish the tones (“attend” condition). The desired response occurs only in the latter condition.

Keywords:   P300 potentials, stimuli, sensory modality, organic dementia, pseudodementia, ignore condition, attend condition

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