Ezra Susser, Sharon Schwartz, Alfredo Morabia, and Evelyn Bromet

Print publication date: 2006

Print ISBN-13: 9780195101812

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780195101812.001.0001

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ContentsFRONT MATTER

Title Pages
Dedication
Foreword
Preface
References
[UNTITLED]
Acknowledgments
Contributors
I Psychiatric Epidemiology, Then And Now
- 1 The Burden of Mental Illness
- 2 The Arc of Epidemiology
- 3 Searching for the Causes of Mental Disorders
II Risk Factors As Causes Of Mental Disorders
- 4 What Is a Cause?
- 5 Detecting Causes
- 6 Study Designs
- 7 Relationships among Causes
- 8 Measures of Association
III Cohort Designs In Psychiatric Epidemiology
- 9 Prototypical Cohort Study
- 10 Diversity of Cohort Studies
- 11 Causal Inference: A Thought Experiment
- 12 Confounding: What It Is and What Can Be Done
- 13 Unequal Attrition under Different Types of Follow-Up
- 14 Differential Misclassification
IV Case-Control Designs in Psychiatric Epidemiology
- 15 Logic of the Case-Control Design
- 16 Applications of the Case-Control Study
- 17 Choosing Controls
- 18 Comparability and the Case-Control Study
V Case-Control Designs in Biologic Psychiatry
- 19 Biologic Studies in Psychiatry
- 20 Choosing Cases in Biologic Psychiatry
- 21 Choosing Controls in Biologic Psychiatry
VI Analyzing The Data
- 22 Gauging the Precision of Measures of Association
- 23 Using Significance Tests in Establishing Associations
- 24 Planning Studies: Estimating Power and Sample Size
- 25 Adjustment for Covariates
- 26 Event Time Analysis
- 27 Assessing Heterogeneity of Effects
VII The Search For Genetic Causes Of Mental Disorders
- 28 Integrating Epidemiology with Genetics
- 29 Genetic Association Studies
- 30 Modern Family History Studies
- 31 Twin Studies of Heritability
- 32 Genetic Linkage Studies
- 33 Designs for the Genomic Era
VIII Complex Causal Relationships
- 34 Eco-Epidemiology
- 35 Causal Explanation within a Risk Factor Framework
- 36 Causal Explanation Outside the Black Box
- 37 Dependent and Dynamic Processes
END MATTER
Appendix A Our Approach to Epidemiologic Concepts and Methods
References
[UNTITLED]
Appendix B Application of Survival Analysis to Prenatal Determinants of Schizophrenia Example (PDSE) Data
References
Glossary
Index

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Causal Explanation within a Risk Factor Framework

Chapter:: (p. 422 ) 35 Causal Explanation within a Risk Factor Framework
Source:: Psychiatric Epidemiology
Author(s):: Ezra Susser
Sharon Schwartz
Alfredo Morabia
Evelyn J. Bromet
Publisher:: Oxford University Press

DOI:10.1093/acprof:oso/9780195101812.003.35

This chapter focuses on construct validity and external validity. Causal explanation enhances research endeavors both by increasing researchers' confidence in the causal effect of their risk factors and by delineating the extent to which the results of their study applies to other populations. Within the risk factor paradigm, construct validity and external validity form the basis of causal explanation.

Keywords: construct validity, extenal validity, exposure, disease, causal explanation, risk factor

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Ezra Susser, Sharon Schwartz, Alfredo Morabia, and Evelyn Bromet

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Causal Explanation within a Risk Factor Framework

Ezra Susser

Sharon Schwartz

Alfredo Morabia

Evelyn J. Bromet