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The Cortical Neuron$
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Michael J. Gutnick and Istvan Mody

Print publication date: 1995

Print ISBN-13: 9780195083309

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780195083309.001.0001

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Measurement of Cortical Neurotransmitter Receptors with Radioligand Binding: Insights into the Mechanisms of Kindling-Induced Epilepsy

Measurement of Cortical Neurotransmitter Receptors with Radioligand Binding: Insights into the Mechanisms of Kindling-Induced Epilepsy

Chapter:
(p.264) Chapter 19 Measurement of Cortical Neurotransmitter Receptors with Radioligand Binding: Insights into the Mechanisms of Kindling-Induced Epilepsy
Source:
The Cortical Neuron
Author(s):

John E. Kraus

James O. McNamara

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195083309.003.0019

Understanding the pathophysiology of partial epilepsy in molecular terms will likely facilitate the development of new and more effective therapies. One approach is to analyze the mechanisms underlying the hyperexcitability in an animal model in the hope that analogous mechanisms are operative in some forms of the human condition. This thinking led the authors to embark on studies of the kindling model of epilepsy in the late 1970s. This chapter describes the kindling model; outlines the rationale for use of radioligand binding as a tool; considers the advantages and disadvantages of this approach; summarizes the findings of a host of such studies in the kindling model; and reviews a few of these findings as a means of illustrating the value of such approaches.

Keywords:   epilepsy, kindling model, radioligand binding, neurotransmitters

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