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The AxonStructure, Function and Pathophysiology$
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Stephen G. Waxman, Jeffery D. Kocsis, and Peter K. Stys

Print publication date: 1995

Print ISBN-13: 9780195082937

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195082937.001.0001

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Voltage-clamp studies in axons: Macroscopic and single-channel currents

Voltage-clamp studies in axons: Macroscopic and single-channel currents

Chapter:
(p.257) 13 Voltage-clamp studies in axons: Macroscopic and single-channel currents
Source:
The Axon
Author(s):

WERNER VOGEL

JÜRGEN R. SCHWARZ

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195082937.003.0013

This chapter describes macroscopic membrane currents measured in amphibian and mammalian nodes of Ranvier with the voltage-clamp method. These results are compared with those of single-channel recordings, which provide important data on channel characteristics in myelinated axons. The results obtained from the calculation of the action potentials with voltage-clamp data obtained from frog, rat, and human nerve fibers are also reviewed. It is shown that the properties of the various new ionic channel types detected with the patch-clamp technique help explain previously unsolved problems concerning the ionic basis of accommodation, resting potential, and various pathophysiological phenomena.

Keywords:   membrane currents, amphibians, mammals, nodes of Ranvier, voltage-clamp method, action potentials

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