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The Head-Neck Sensory Motor System$
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Alain Berthoz, Werner Graf, and P. P. Vidal

Print publication date: 1992

Print ISBN-13: 9780195068207

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780195068207.001.0001

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Effects of N-Methyl-d-Aspartate Receptor Antagonists on Vestibular Compensation in the Guinea Pig: In Vivo and In Vitro Studies

Effects of N-Methyl-d-Aspartate Receptor Antagonists on Vestibular Compensation in the Guinea Pig: In Vivo and In Vitro Studies

Chapter:
(p.631) Chapter 104 Effects of N-Methyl-D-Aspartate Receptor Antagonists on Vestibular Compensation in the Guinea Pig: In Vivo and In Vitro Studies
Source:
The Head-Neck Sensory Motor System
Author(s):

Paul F. Smith

Cynthia L. Darlington

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195068207.003.0104

This study investigates the contribution of NMDA receptors to vestibular compensation for UL in the guinea pig using the NMDA receptor/channel antagonists. Three experimental approaches were taken to examine the effect of NMDA antagonists on vestibular compensation. The results imply that NMDA receptor antagonists interfere with vestibular compensation during a limited period following UL. It is found that noncompetitive NMDA antagonists MK801 have a binding site similar to dissociative anesthetics such as ketamine.

Keywords:   NMDA antagonists, ketamine, vestibular compensation, NMDA receptor, dissociative anesthetics, binding site

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