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Receptor and Ion-Channel TraffickingCell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels$
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Stephen J. Moss and Jeremy Henley

Print publication date: 2002

Print ISBN-13: 9780192632241

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192632241.001.0001

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Voltage-gated sodium channels

Voltage-gated sodium channels

Chapter:
(p.2) (p.3) Chapter 1 Voltage-gated sodium channels
Source:
Receptor and Ion-Channel Trafficking
Author(s):

Misbah Malik-Hall

John N. Wood

Kenji Okuse

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192632241.003.0001

It is known that the neuron-specific pattern of transcription of some voltage-gated sodium channels (VGSCs) is regulated by a specific sequence, the NRSE/RE1 (neuron-restricted silencing element) and its cognate binding protein. In addition, a role for accessory subunits in high-level channel expression and channel anchoring with respect to extracellular signals is also now established. More recently, signals ranging from growth factors such as GDNF to nerve damage or demyelinating diseases have been shown to alter the cohort of sodium (Na) channels expressed in neurons and may also alter their spatial pattern of expression. This chapter focuses on the possible regulatory role of accessory subunits that have been found to associate with Na channel α subunits, and factors that alter channel expression.

Keywords:   VGSCs, demyelinating diseases, extracellular signals, nerve damage, sodium channels, neurons, channel expression

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