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Antenatal and Neonatal Screening
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Antenatal and Neonatal Screening

Nicholas Wald and Ian Leck

Abstract

The options in antenatal and neonatal care are legion. Preferences still tend to be subjective. In spite of much publicity that has raised public expectation, an up-to-date thorough evaluation of antenatal and neonatal screening has been lacking. This book sets out the principles and theory of screening using single and multiple markers. It emphasizes the need to examine screening approaches in a quantitative manner and aims to help enable choices to be based on objective evidence of efficacy safety, and cost — essential in determining public health policy. Technical advances have sometimes be ... More

Keywords: antenatal screening, neontal screening, efficacy, safety, abnormality detection, technical procedures, problems areas, research needs

Bibliographic Information

Print publication date: 2000 Print ISBN-13: 9780192628268
Published to Oxford Scholarship Online: September 2009 DOI:10.1093/acprof:oso/9780192628268.001.0001

Authors

Affiliations are at time of print publication.

Nicholas Wald, editor
Wolfson Institute, University of London

Ian Leck, editor
University of Manchester

Contents

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I Principles of screening

1 Tests using single markers

Howard S. Cuckle, and Nicholas Wald

2 Tests using multiple markers

Nicholas Wald, and Allan Hackshaw

II Screening for specific disorders

(a) Antenatal screening

3 Neural tube defects

Nicholas Wald

4 Down’s syndrome

Nicholas Wald

5 X-linked disorders

Sarah Bundey

6 Tay–Sachs disease

Feige Kaplan, and Charles R. Scriver

7 Infections

Catherine S. Peckham, and Marie-Louise Newell

9 Disorders associated with high blood pressure

Michael de Swiet, and Ian Leck

10 Acquired haematological disorders

Elizabeth A. Letsky, and Sir David Weatherall

(b) Antenatal and neonatal screening

11 Genetic haematological disorders

Sir David Weatherall, and Elizabeth A. Letsky

12 Rhesus and other haemolytic diseases

Elizabeth A. Letsky, Ian Leck, and John M. Bowman

13 Cystic fibrosis

David J. H. Brock

(c) Neonatal screening

15 Congenital hypothyroidism

Joseph G. Hollowell, Bradford L. Therrell, and W. Harry Hannon

III Certain procedures used in screening programmes

18 Ultrasound scanning for congenital abnormalities

Nicholas Wald, Anne Kennard, Alan Donnenfeld, and Ian Leck

19 Amniocentesis and chorionic villus sampling

Christine Gosden, Ann Tabor, Ian Leck, Adrian Grant, Zarko Alfirevic, and Nicholas Wald

20 Fetal blood and tissue sampling

Pauline A. Hurley, and Charles H. Rodeck

IV Wider issues

22 Ethics of antenatal and neonatal screening

Nicholas Wald, Ian Leck, and J. A. Muir Gray

23 Conclusions

Nicholas Wald, and Ian Leck