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Oncology for Palliative Medicine$
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Peter Hoskin and Wendy Makin

Print publication date: 2003

Print ISBN-13: 9780192628114

Published to Oxford Scholarship Online: November 2011

DOI: 10.1093/acprof:oso/9780192628114.001.0001

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Cancer biology

Cancer biology

Chapter:
(p.7) Chapter 2 Cancer biology
Source:
Oncology for Palliative Medicine
Author(s):

Peter Hoskin

Wendy Makin

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192628114.003.0002

Malignant cells differ from normal tissues in a number of fundamental properties. The malignancy in cells is a result of the changes in the genetic make-up of the cells. Changes in the sequences of the DNA due to amplification of protein production are associated with the development and maintenance of malignant growth. Furthermore, changes in cell regulation and tissue growth also lead to malignancy. This chapter focuses on the biological issues of cancer to equip readers with a comprehensive background on the processes by which a malignant growth can cause symptoms from both the local and metastatic sides and by which malignancy can cause death. Discussions in it include the aetiology of cancer, the different stages of carcinogenesis, the high incidence of cancer due to genetic factors and gene abnormality, and the history and progression of malignant disease.

Keywords:   malignant cells, malignancy, cells, DNA, cell regulation, tissue growth, biological issues, carcinogenesis, genetic factors, gene abnormality

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