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Design Concepts in Nutritional Epidemiology$
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Barrie M. Margetts and Michael Nelson

Print publication date: 1997

Print ISBN-13: 9780192627391

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780192627391.001.0001

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11. Gene–nutrient interactions in nutritional epidemiology

11. Gene–nutrient interactions in nutritional epidemiology

Chapter:
(p.312) 11. Gene–nutrient interactions in nutritional epidemiology
Source:
Design Concepts in Nutritional Epidemiology
Author(s):

Lenore Kohlmeier

David DeMarini

Walter Piegorsch

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192627391.003.0011

There is increasing evidence that the ways in which nutrients are handled metabolically is, to a greater or lesser extent, under genetic control. Equally, nutrient (and non-nutrient) intakes affect the expression of genetic predispositions. These complex interactions (nutrient regulation of gene transcription, food-induced DNA damage, phytochemical enhancement or protection of DNA integrity, genetic susceptibility to nutrition-related diseases) increasingly shed light on epidemiological relationships between diet and health and disease. This chapter considers design and analytical implications for understanding gene-nutrient interactions, including specific statistical models. It concludes with a discussion of ethical issues, and an appendix for sample size determination in relation to the determination of genetic characteristics in nutritional epidemiological studies.

Keywords:   genetics, gene-nutrient interactions, DNA damage, DNA integrity, sample size, ethics

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