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The NMDA Receptor$
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G. L. Collingridge and J. C. Watkins

Print publication date: 1995

Print ISBN-13: 9780192625021

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192625021.001.0001

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Anatomical, pharmacological, and molecular diversity of native NMDA receptor subtypes

Anatomical, pharmacological, and molecular diversity of native NMDA receptor subtypes

Chapter:
(p.158) 6 Anatomical, pharmacological, and molecular diversity of native NMDA receptor subtypes
Source:
The NMDA Receptor
Author(s):

DANIEL T. MONAGHAN

AMY L. BULLER

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192625021.003.0006

This chapter compares the anatomical and pharmacological properties of the recombinant NMDA receptor subunits with the properties of native NMDA receptor subtypes. It first summarizes the anatomical distribution of individual receptor subunits and then compares their distributions with those of NMDA receptor subtypes identified in radio ligand binding studies. Radioligand binding studies indicate the presence of at least four pharmacologically distinct populations of NMDA receptors with differing regional distributions. There is substantial regional variation among members of both the NR1 and NR2 subunit families; however, the distributions of the NR2 subunits correspond much more closely to the distributions of the pharmacologically distinct NMDA receptor populations.

Keywords:   NDMA receptors, anatomical features, ligand binding, receptor subtypes, pharmacological properties

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