Jump to ContentJump to Main Navigation
The NMDA Receptor$
Users without a subscription are not able to see the full content.

G. L. Collingridge and J. C. Watkins

Print publication date: 1995

Print ISBN-13: 9780192625021

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192625021.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2018. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a monograph in OSO for personal use (for details see www.oxfordscholarship.com/page/privacy-policy).date: 17 January 2019

Non-competitive antagonists of N-methyl-D-aspartate

Non-competitive antagonists of N-methyl-D-aspartate

(p.105) 3 Non-competitive antagonists of N-methyl-D-aspartate
The NMDA Receptor




Oxford University Press

The ability of d-α-aminoadipate (DAA) and a range of related substances to act as amino acid antagonists has been found to parallel the ability of these substances to displace binding of tritiated ligands from the recognition site of the NMDA receptor. Important exceptions include Mg2+ and HA-966, which do not displace [3H] d-2-amino-5-phosphonovalerate (d-AP5), a competitive-type NMDA receptor antagonist, from rat brain binding sites. Several other groups of compounds joined this ‘non-competitive’ list in the 1980s and 1990s. This chapter concentrates on chemicals acting at sites other than that for NMDA recognition but which nevertheless influence the functions of the NMDA receptor channel complex.

Keywords:   NMDA receptor, NMDA, DAA, tritiated ligands

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .