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The NMDA Receptor$
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G. L. Collingridge and J. C. Watkins

Print publication date: 1995

Print ISBN-13: 9780192625021

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192625021.001.0001

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The NMDA receptor in epilepsy

The NMDA receptor in epilepsy

Chapter:
(p.395) 17 The NMDA receptor in epilepsy
Source:
The NMDA Receptor
Author(s):

SUZANNE CLARK

STEVEN STASHEFF

DARRELL V. LEWIS

DAVID MARTIN

WILKIE A. WILSON

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192625021.003.0017

Few things have generated more excitement in the field of epilepsy than studies suggesting that N-methyl-d-aspartate (NMDA) receptors may play a role in the development and expression of seizures. It is possible that antagonists of the NMDA receptor channel complex may become a new class of anti-epileptic drugs which not only suppress seizures, but in some cases may be able to prevent the development of the epileptic condition altogether. Given the significance of the latter possibility, it is not surprising that the NMDA receptor has become the focus of intense study. A wealth of new pharmacologic agents has been developed that has facilitated a wide range of in vivo and in vitro studies. This chapter briefly reviews some of the earlier studies and then focuses on the large number of recent advances.

Keywords:   NMDA receptors, epilepsy, seizures, antagonists, pharmacologic agents

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