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The NMDA Receptor$
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G. L. Collingridge and J. C. Watkins

Print publication date: 1995

Print ISBN-13: 9780192625021

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192625021.001.0001

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Clinical implications of NMDA receptors

Clinical implications of NMDA receptors

(p.376) 16 Clinical implications of NMDA receptors
The NMDA Receptor


Oxford University Press

Studies on the physiology and pharmacology of excitatory amino acids led to a new understanding of the high degree of complexity of excitatory transmission in the brain, far removed from the early concept that post-synaptic depolarization caused excitation and hyperpolarization inhibition. As a consequence of this recent knowledge, workers in the field have proposed therapeutic applications for drugs modulating excitatory amino acid systems, ranging across the entire field of psychiatry and neurology, although only a very limited number of such compounds have reached the stage of clinical evaluation. This chapter attempts to summarize the proposed therapeutic applications for drugs modulating excitatory amino acids and provides a short description of the rationale which led to these proposals. The emphasis is on NMDA-modulating compounds, but there is also mention of possible clinical applications for compounds acting at non-NMDA receptors.

Keywords:   NMDA receptors, excitatory amino acids, depolarization, hyperpolarization, therapeutic applications, psychiatry, neurology

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