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The NMDA Receptor$
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G. L. Collingridge and J. C. Watkins

Print publication date: 1995

Print ISBN-13: 9780192625021

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192625021.001.0001

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NMDA receptors and long-term potentiation in the hippocampus

NMDA receptors and long-term potentiation in the hippocampus

Chapter:
(p.294) 13 NMDA receptors and long-term potentiation in the hippocampus
Source:
The NMDA Receptor
Author(s):

ZAFAR I. BASHIR

NICOLA BERRETTA

ZUNER A. BORTOLOTTO

KATH CLARK

CERI H. DAVIES

BRUNO G. FRENGUELLI

JENNI HARVEY

BRIGITTE POTIER

GRAHAM L. COLLINGRIDGE

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192625021.003.0013

N-methyl-d-aspartate (NMDA) receptors have been shown to have two important physiological roles in the vertebrate central nervous system; they are mediators of synaptic transmission in many pathways in the brain and they are critically involved in neuronal plasticity. This chapter considers long-term potentiation (LTP) in the hippocampus, the first identified and most extensively investigated form of plasticity involving NMDA receptors. The involvement of NMDA receptors in synaptic transmission in the hippocampus is also considered in detail in view of the inextricable link between synaptic transmission and plasticity that NMDA receptors confer upon a synapse.

Keywords:   LTP, NMDA receptors, synaptic transmission, hippocampus, central nervous system, neuronal plasticity

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