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The NMDA Receptor
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The NMDA Receptor

G. L. Collingridge and J. C. Watkins

Abstract

This book comprises coverage of the NMDA receptor. The NMDA receptor is an important protein in the brain, which is involved in physiological processes such as synaptic transmission and synaptic plasticity, which may underlie learning and memory. Pathological changes involving the NMDA receptors probably contribute to the development of epilepsy, acute neuronal damage such as that resulting from stroke and chronic neuropathologies such as Alzheimer's disease. There is considerable interest in the development of pharmacological agents active at NMDA receptors as new therapeutic agents. Each cha ... More

Keywords: NMDA receptor, physiological processes, synaptic transmission, synaptic plasticity, pathological change, epilepsy, neuronal damage, stroke, neuropathologies, molecular biology

Bibliographic Information

Print publication date: 1995 Print ISBN-13: 9780192625021
Published to Oxford Scholarship Online: March 2012 DOI:10.1093/acprof:oso/9780192625021.001.0001

Authors

Affiliations are at time of print publication.

G. L. Collingridge, editor
University of Birmingham

J. C. Watkins, editor
University of Bristol

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Contents

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3 Non-competitive antagonists of N-methyl-D-aspartate

DAVID LODGE, MARTYN JONES, and ELIZABETH FLETCHER

4 NMDA receptor agonists and competitive antagonists

MARK L. MAYER, MORRIS BENVENISTE, and DORIS K. PATNEAU

5 Molecular biology of NMDA receptors

P. H. SEEBURG, H. MONYER, R. SPRENGEL, and N. BURNASHEV

8 The time course of NMDA receptor-mediated synaptic currents

ROBIN A. J. LESTER, JOHN D. CLEMENTS, GANG TONG, GARY L. WESTBROOK, and CRAIG E. JAHR

9 Activation of NMDA receptors

A. J. GIBB, B. EDMONDS, R. A. SILVER, S. G. CULL-CANDY, and D. COLQUHOUN

13 NMDA receptors and long-term potentiation in the hippocampus

ZAFAR I. BASHIR, NICOLA BERRETTA, ZUNER A. BORTOLOTTO, KATH CLARK, CERI H. DAVIES, BRUNO G. FRENGUELLI, JENNI HARVEY, BRIGITTE POTIER, and GRAHAM L. COLLINGRIDGE

17 The NMDA receptor in epilepsy

SUZANNE CLARK, STEVEN STASHEFF, DARRELL V. LEWIS, DAVID MARTIN, and WILKIE A. WILSON

19 Competitive NMDA antagonists as drugs

B. S. MELDRUM, and A. G. CHAPMAN

20 Non-competitive NMDA antagonists as drugs

L. L. IVERSEN, and J. A. KEMP

End Matter