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5-Hydroxytryptamine in PsychiatryA Spectrum of Ideas$
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Merton Sandler, Alec Coppen, and Sara Harnett

Print publication date: 1991

Print ISBN-13: 9780192620118

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192620118.001.0001

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Anxiogenic effect of the 5-HT1C agonist m-chlorophenylpiperazine

Anxiogenic effect of the 5-HT1C agonist m-chlorophenylpiperazine

(p.198) 16. Anxiogenic effect of the 5-HT1C agonist m-chlorophenylpiperazine
5-Hydroxytryptamine in Psychiatry

G. Curzon

G. A. Kennett

P. Whitton

Oxford University Press

The earlier literature on l-(3-chlorophenyl)piperazine (m-CPP) and l-[3-(trifluoromethyl)phenyl] piperazine (TFMPP) describes these compounds mainly as agonists at the IB subtype of 5-hydroxytryptamine (5-HT, serotonin) receptors. However, many findings suggest that their hypolocomotor and hypophagic effects are mediated by stimulation of 5-HTlc receptors. As m-CPP causes anxiety in humans it was investigated whether m-CPP and TFMPP had anxiogenic-like effects in rats. The results indicate that this occurs and is mediated by hippocampal 5-HTlc receptors.

Keywords:   hypolocomotor, TFMPP, m-chlorophenylpiprazine, trifluoromethylphenyl piprazine, anxiogenic, 5-hydroxytryptamine

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