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Migraine: A Spectrum of Ideas$
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Merton Sandler and Geralyn M. Collins

Print publication date: 1990

Print ISBN-13: 9780192618108

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192618108.001.0001

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A classification of peripheral analgesics based upon their mode of action

A classification of peripheral analgesics based upon their mode of action

Chapter:
(p.59) 6. A classification of peripheral analgesics based upon their mode of action
Source:
Migraine: A Spectrum of Ideas
Author(s):

Sérgio H. Ferreira

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192618108.003.0006

This chapter aims to discuss current ideas about the mechanism of action of peripheral analgesics, and to provide a rational basis both for their therapeutic use and for the development of new drugs. The classical explanation for the mechanism of inflammatory hyperalgesia is that it results from excitatory actions of endogenous mediators that are released by inflamed or damaged tissues. This concept implies that there are many mediators present, in what might be called a ‘mediator soup’. If the concentration of one or several agonists in this ‘mediator soup’ is increased, as a result of further stimulation, activation of the nociceptor is achieved. The concept also implies that all types of nociceptive mediator are qualitatively similar — that is, that they are all equally capable of activating the nociceptors.

Keywords:   peripheral analgesics, therapeutic use, new drugs, drug development, inflammatory hyperalgesia, excitatory actions

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