Genetic epidemiology of migraine
The hereditary nature of migraine has been reported consistently since it was first noted by S. A. Tissot in the 18th century. Indeed, the association between migraine and family history was believed to be so strong that it was included as a criterion for diagnosing migraine in the definition adopted by the Ad Hoc Committee on the classification of headache in 1962. The most recent catalogue of Mendelian diseases in humans lists migraine as an autosomal dominant condition. Nevertheless, both the role of genetic factors in the pathogenesis of migraine and its mode of inheritance continue to be elusive.
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