The current status of migraine therapy
A recent method of preventing migraine attack has been tried on patients with premonitory symptoms, for example, irritability, excitement, euphoria, or food cravings that occur as long as twenty-four hours before the attack; these patients have been given domperidone, a dopamine D2 receptor antagonist, which is anti-emetic (that is, relieving nausea and vomiting) and gastro-kinetic (that is, stimulating the stomach and opening the pyloric spincter so that oral medication can be absorbed by the small gut). With premonitory symptoms of more than six hours, it can be effective in preventing migraine attacks. There is still no general agreement as to how migraine is best treated, largely because of the fact that many drugs which are used have not been scientifically evaluated by methodologically sound clinical trials.
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