Differential abnormalities in signal transduction in migraine and cluster headache
Over the past few years a biochemical approach has been used to study the pathogenesis of migraine by looking at transduction mechanisms which would be common to many agents that are putative trigger factors in migraine and would also be common targets for a wide range of drug treatments. Hormones, dietary factors, neurogenic agents such as neurotransmitters, neuropeptides, and other neuromodulators and vasoactive agents are all implicated, most of which would mediate their actions through receptors in the cell membrane. Receptor activation is associated with the generation of second messengers — cyclic AMP (cAMP) from adenylate cyclase, and inositol trisphosphate and diacylglycerol from the polyphosphoinositide system. The second messengers in turn produce their effects by activation of protein kinases or by mobilization of calcium. A number of prophylactic treatments would affect these pathways.
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