General discussion I
This chapter discusses 5-HT uptake, platelets, and migraine. 5-HT (5-hydroxytryptamine; serotonin) has been studied in relation to migraine for about twenty years, but in relation to depression for about thirty years. The relationship between migraine and depression is fascinating. The prodromal symptoms of migraine are very much like those of an affective disorder. Over the last ten years 5-HT uptake by the platelets has been studied with interest. The platelet is readily accessible for study, and some of its transport systems may have something in common with those in the central nervous system.
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